CHARACTERISTICS AND CLASSIFICATION OF TYPE 3 NEOVASCULARIZATION WITH B-SCAN FLOW OVERLAY AND EN FACE FLOW IMAGES OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Issue 1 (January 2020)

• Record Type: Journal Article
• Authors: Kataoka, Keiko; Takeuchi, Jun; Nakano, Yuyako; Fujita, Ai; Kaneko, Hiroki; Ito, Yasuki; Terasaki, Hiroko
• Is Part Of: Retina. Volume 40:Issue 1(2020)
• Publication Date: 2020-01
• Subjects: age-related macular degeneration -- OCT angiography -- type 3 neovascularization; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000002357
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To study B-scan flow overlay and en face flow optical coherence tomography angiography (OCT-A) images of Type 3 neovascularization (NV) and to characterize a staging system for Type 3 NV based on the OCT-A findings. Methods: We retrospectively collected data on consecutive treatment-naive eyes with Type 3 NV. All eyes underwent fluorescein angiography, indocyanine green angiography, structural spectral domain OCT, and OCT-A (AngioPlex). Localization and extension of abnormal flows detected by B-scan flow overlay and en face OCT-A images were assessed. Results: Of 24 eyes of 22 patients with Type 3 NV, B-scan flow overlay images showed that 4.2% had telangiectatic flow in the deep retinal layer without outer plexiform layer disruption (Stage 1), 8.3% had downward intraretinal flow and subretinal flow without retinal pigment epithelium disruption (Stage 2), and 87.5% had downward flow and retinal pigment epithelium disruption (Stage 3). Of the Stage 3 eyes, 95.2% showed flow signal penetrating at the site of the retinal pigment epithelium disruption on the B-scan flow overlay images. Conclusion: We showed the characteristics of Type 3 NV using B-scan flow overlay and en face OCT-A images. B-scan flow overlay OCT-A images seem useful to improve the detection and accurate diagnosis of Type 3 NV. Abstract : Supplemental Digital Content is Available in the Text.This retrospective case series assessed B-scan flow overlay and en face optical coherence tomography angiography images to reveal characteristics of neovascular flow of Type 3 neovascularization and propose a staging system based on the optical coherence tomography angiography findings.