Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases. Issue 1 (January 2020)

• Record Type: Journal Article
• Authors: Uzun, Özcan; Bolu, Abdullah; Taşçi, Azize Beril; Oğur, Begüm
• Is Part Of: Clinical neuropharmacology. Volume 43:Issue 1(2020)
• Publication Date: 2020-01
• Subjects: antipsychotics -- knee buckling -- myoclonus -- schizophrenia; Neuropharmacology -- Periodicals; 615.78
• DOI: 10.1097/WNF.0000000000000370
• Languages: English
• ISSNs: 0362-5664

Abstract

Abstract : Background: Negative myoclonus is rarely seen in the clinical setting. It can be involved in some central nervous system pathologies. It has also been observed after antipsychotic treatment. Case Reports: In this article, we will present 3 cases diagnosed with negative myoclonus in a 120-bed university-affiliated hospital within the past 7 years. Based on our clinical experience, it was observed that myoclonic jerk was a rare condition that started with suddenly dose changes. Patients showed good improvement in response to dose reduction. Conclusions: Since the number of reported cases on negative myoclonus is limited, there is still a lack of well-established consensus on the management of this disease. It can be concluded that myoclonic jerk may be dose-dependent, sudden dose changes may be effective, anticonvulsants are not effective in all cases, and treatment can be achieved by reducing the dose.