Diastolic, but not systolic, blood pressure at admission is associated with aortic-related adverse events in type B dissection after thoracic endovascular aortic repair. (15th January 2020)

• Record Type: Journal Article
• Authors: Lu, Nan; Xu, Tan; He, Zhuoqiao; Zhu, Jinxiu; Yan, Jingyi; Hu, Ping; Wang, Jie; Ma, Xiaojing; Tan, Xuerui
• Is Part Of: International journal of cardiology. Volume 299(2020)
• Page Start: 257
• Page End: 262
• Publication Date: 2020-01-15
• Subjects: Blood pressure -- Type B aortic dissection -- Thoracic endovascular aortic repair -- Adverse events; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2019.07.064
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Hypertension is the most important risk factor for aortic dissection. We aimed to assess the association of systolic blood pressure (SBP) and diastolic blood pressure (DBP) at admission with aortic-related adverse events (ARAE) after thoracic endovascular aortic repair (TEVAR). Methods: All patients (n = 269) admitted with type B aortic dissection (BAD) for TEVAR were included. ARAE at 3, 24, and 60 months were evaluated as outcomes. Cox proportional regression analysis was performed. Results: No variables were found to be predictors of 3-month ARAE by multiple analysis. Independent predictors of 24-month ARAE were DBP at admission (hazard ratio [HR] per 10 mm Hg decrement, 1.318; 95% confidence interval [CI] 1.059–1.641; p = 0.013), cerebrovascular accident (HR 1.965; 95% CI 1.097–3.522; p = 0.023) and obesity (HR 2.922; 95% CI 1.096–7.795; p = 0.032). DBP at admission (HR per 10 mm Hg decrement, 1.276; 95% CI 1.038–1.569; p = 0.021) was also a predictor of 60-month ARAE. In the non-chronic group (n = 223), DBP at admission was evaluated as an independent predictor of 3-month (HR per 10 mm Hg decrement, 1.809; 95% CI 1.084–3.018; p = 0.023), 24-month (HR per 10 mm Hg decrement, 1.344; 95% CI 1.070–1.688; p = 0.011) and 60-month (HR per 10 mm Hg decrement, 1.338; 95% CI 1.065–1.682; p = 0.013) ARAE. In the chronic group (n = 46), no variables were found to be independent predictors of 3-month, 24-month, or 60-month ARAE. Conclusions: DBP at admission can predict ARAE in patients with BAD after TEVAR, whereas SBP was not associated with ARAE. The relationship between DBP at admission and outcomes appears to be more prominent in non-chronic patients. Highlights: In BAD patients after TEVAR, DBP at admission was associated with 24-month and 60-month ARAE. In non-chronic patients, DBP at admission was associated with 3-month, 24-month, and 60-month ARAE. SBP at admission was not associated with ARAE at any time period, regardless of the stage of BAD.