Therapeutic Role of Mobilized Bone Marrow Cells in Children with Nonischemic Dilated Cardiomyopathy. (21st October 2012)

• Record Type: Journal Article
• Authors: Habeeb, Nevin M.; Youssef, Omneya I.; El Hadidi, Eman S.
• Other Names: Berkowitz C. D. Academic Editor.; Law Y. M. Academic Editor.; Overturf G. D. Academic Editor.
• Is Part Of: ISRN pediatrics. Volume 2012(2012)
• Publication Date: 2012-10-21
• Subjects: Pediatrics -- Periodicals; Pediatrics; Pediatrics; Periodicals; 618.92
• DOI: 10.5402/2012/927968
• Languages: English
• ISSNs: 2090-469X

Abstract

Abstract : Dilated cardiomyopathy is an important cause of congestive cardiac failure in infants and children. Mobilizing hematopoietic progenitor cells is a promising intervention to this deadly disease. Aim . Evaluate granulocyte colony stimulating factor (GCSF) as therapeutic modality in children with idiopathic dilated cardiomyopathy (IDCM). Subjects and Methods . This case-control prospective study was conducted on 20 children with IDCM following up at Cardiology Clinic Children's Hospital, Ain Shams University (group 1) who were compared to another 10 age-, sex-, duration-of-illness-, and systolic-function-matched children with IDCM as control (group 2). They were subjected to history taking, clinical examination, echocardiography, and peripheral blood CD34+ cell assessment before and one week after GCSF intake for 5 consecutive days (by group 1 but not group 2). Results . A significant improvement in echocardiographic data and CD34+-T-cell increase was found in group 1 one week after GCSF intake and for the next 6 months CD34+ T cells percentage of change showed no significant correlation with the that of the left ventricular dimensions and systolic function. Conclusion . Administration of GCSF to children with IDCM resulted in clinical and echocardiographic improvement not correlated to mobilized CD34+ T cells, implying involvement of additional mechanisms over simple stem cell mobilization.