Anticoagulation and antibacterial properties of heparinized nanosilver with different morphologies. (15th August 2021)

• Record Type: Journal Article
• Authors: Meher, Mukesh Kumar; Poluri, Krishna Mohan
• Is Part Of: Carbohydrate polymers. Volume 266(2021)
• Publication Date: 2021-08-15
• Subjects: Heparin -- Silver nanoparticles -- Heparinized nanosilver -- Morphology -- Anticoagulants -- Antibacterial agents; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118124
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Synthesis and characterization of nanoparticles with different morphologies coupled to minimal chemical interventions for sustainable applications is one of the contemporary topics in the field of nanotechnology. In the current study, heparinized silver nanoparticles were synthesized using a chemical reduction method. Different concentrations of heparin were used to investigate its role in the stability and morphological properties of silver nanoparticles. Interestingly, it has been observed that the concentration of the stabilizing agent heparin plays a pivotal role in dictating the size and shape of the nanosilver. As visualized under a transmission electron microscope, nanosilver with different morphological states such as triangles, truncated triangles, hexagon, and spheres has been experimentally trapped. Such modular property of heparin coated nanosilver has also exhibited substantial differences in their anticoagulation and antimicrobial activities. Graphical abstract: Unlabelled Image Highlights: Different morphological structures of heparinized nanosilver were trapped. Heparin to silver concentration regulates the nanoparticle size and shape. Hexagonal AgNPs-HP exhibited highest anticoagulant activity. Morphologically distinct AgNPs-HP possess similar antimicrobial properties.