Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4+ cells. (1st January 2019)

• Record Type: Journal Article
• Authors: Choi, Eun-Ju; Ryu, Young Bae; Tang, Yujiao; Kim, Bo Ram; Lee, Woo Song; Debnath, Trishna; Fan, Meiqi; Lee, Hyun-Su; Kim, Eun-Kyung
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 34:Number 1(2019)
• Page Start: 613
• Page End: 619
• Publication Date: 2019-01-01
• Subjects: Atopic dermatitis -- cinnamamides -- Th1/Th2 cytokines -- IL-4 -- CD4+ T cells; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2019.1569647
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, ( E )-3-(4-hydroxyphenyl)- N -phenylethyl acrylamide (NCT) and N - trans -coumaroyltyramine (NCPA), were determined on AD by orally administering them to mice. Oral administration of the cinnamamides ameliorated the increase in epidermal and dermal thickness as well as mast cell infiltration. Cinnamamides suppressed serum immunoglobulin (Ig) levels and expression of T-helper (Th)1/Th2 cytokines. Moreover, cinnamamides suppressed interleukin (IL)-4, which plays a crucial role in preparing naïve clusters of differentiation (CD)4 + T cells, and decreased the cervical lymph node size and weight. Interestingly, in almost all cases, NCPA exhibited higher anti-AD activity compared to NCT. These results strongly indicate that NCPA may have potential as an anti-AD agent, and further mechanistic comparative studies of NCT and NCPA are required to determine the cause of differences in biological activity.