Quantifying Solid-State Mixtures of Crystalline Indomethacin by Raman Spectroscopy Comparison with Thermal Analysis. (6th February 2012)

• Record Type: Journal Article
• Authors: Atef, Eman; Chauhan, Harsh; Prasad, Dev; Kumari, Dunesh; Pidgeon, Charles
• Other Names: Nageswara Rao R. Academic Editor.
• Is Part Of: ISRN chromatography. Volume 2012(2012)
• Publication Date: 2012-02-06
• Subjects: Chromatographic analysis -- Periodicals; Chromatographic analysis; Electronic journals; Periodicals; Electronic journals; 543.8
• DOI: 10.5402/2012/892806
• Languages: English
• ISSNs: 2090-8636

Abstract

Abstract : This paper investigates Raman spectroscopy as a quick and reliable method to quantify the alpha ( α ) and gamma ( γ ) polymorphic forms of indomethacin compared to differential scanning calorimetry (DSC). Binary mixtures with different ratios of α and γ indomethacin were prepared and analyzed by Raman and DSC. The Raman method was found to be more reliable and superior compared to DSC. The partial conversion of the alpha to gamma polymorphic form during the DSC measurement was the major limitation for the use of full DSC as a quantitative method and resulted in difference between the calculated and measured enthalpy of both polymorphic forms.