Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression. (2nd January 2019)

• Record Type: Journal Article
• Authors: Wu, Qi; Sun, Si; Li, Zhiyu; Yang, Qian; Li, Bei; Zhu, Shan; Wang, Lijun; Wu, Juan; Yuan, Jingping; Wang, Changhua; Li, Juanjuan; Sun, Shengrong
• Is Part Of: Adipocyte. Volume 8:Number 1(2019)
• Page Start: 31
• Page End: 45
• Publication Date: 2019-01-02
• Subjects: Breast cancer -- exosomes -- cachexia -- tumour progression; Fat cells -- Periodicals; Adipocytes -- Periodicals; 611.018276
• DOI: 10.1080/21623945.2018.1551688
• Languages: English
• ISSNs: 2162-3945

Abstract

ABSTRACT: Cancer-secreted exosomes are emerging mediators of cancer-associated cachexia. Here, we show that miR-155 secreted by breast cancer cells is a potent role on the catabolism of adipocytes and muscle cells through targeting the PPARγ. After cocultivated with mature adipocytes or C2C12, tumour cells exhibit an aggressive phenotype via inducing epithelial-mesenchymal transition while breast cancer-derived exosomes increased catabolism and release the metabolites in adipocytes and muscle cells. In adipocytes, cancer cell-secreted miR-155 promotes beige/brown differentiation and remodel metabolism in resident adipocytes by downregulating the PPARγ expression, but does not significantly affect biological conversion in C2C12. Likewise, propranolol ameliorates tumour exosomes-associated cachectic wasting through upregulating the PPARγ expression. In summary, we have demonstrated that the transfer of miR-155 from exosomes acts as an oncogenic signal reprograming systemic energy metabolism and leading to cancer-associated cachexia in breast cancer.