Ribosomal RNA genes shape chromatin domains associating with the nucleolus. (1st January 2019)

• Record Type: Journal Article
• Authors: Picart-Picolo, Ariadna; Picault, Nathalie; Pontvianne, Frédéric
• Is Part Of: Nucleus. Volume 10:Number 1(2019)
• Page Start: 67
• Page End: 72
• Publication Date: 2019-01-01
• Subjects: Chromatin -- genome organization -- nucleolus -- rRNA genes; Cell nuclei -- Periodicals; Biology -- Periodicals; Biology; Cell nuclei; Periodicals; 571.6605
• DOI: 10.1080/19491034.2019.1591106
• Languages: English
• ISSNs: 1949-1034

Abstract

ABSTRACT: Genomic interactions can occur in addition to those within chromosome territories and can be organized around nuclear bodies. Several studies revealed how the nucleolus anchors higher order chromatin structures of specific chromosome regions displaying heterochromatic features. In this review, we comment on advances in this emerging field, with a particular focus on a recent study published by Quinodoz et al ., that developed a new method to characterize simultaneous genomic interactions in the same cell. Highlighting studies conducted in animal and plant cells, we then discuss the establishment of inactive chromatin at nucleolus organizer region (NOR)-bearing chromosomes.