Study protocol for the PURSUIT-HFpEF study: a Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction. Issue 10 (15th October 2020)

• Record Type: Journal Article
• Authors: Suna, Shinichiro; Hikoso, Shungo; Yamada, Takahisa; Uematsu, Masaaki; Yasumura, Yoshio; Nakagawa, Akito; Takeda, Toshihiro; Kojima, Takayuki; Kida, Hirota; Oeun, Bolrathanak; Sunaga, Akihiro; Kitamura, Tetsuhisa; Dohi, Tomoharu; Okada, Katsuki; Mizuno, Hiroya; Nakatani, Daisaku; Iso, Hiroyasu; Matsumura, Yasushi; Sakata, Yasushi
• Other Names: author non-byline.; Sakata Yasushi author non-byline.; Hikoso Shungo author non-byline.; Nakatani Daisaku author non-byline.; Mizuno Hiroya author non-byline.; Suna Shinichiro author non-byline.; Okada Katsuki author non-byline.; Dohi Tomoharu author non-byline.; Kojima Takayuki author non-byline.; Sunaga Akihiro author non-byline.; Kida Hirota author non-byline.; Bolrathanak Oeun author non-byline.; Tamaki Shunsuke author non-byline.; Fukunami Masatake author non-byline.; Hayashi Takaharu author non-byline.; Higuchi Yoshiharu author non-byline.; Masuda Masaharu author non-byline.; Asai Mitsutoshi author non-byline.; Mano Toshiaki author non-byline.; Fuji Hisakazu author non-byline.; Masuda Daisaku author non-byline.; Takeda Yoshihiro author non-byline.; Nagai Yoshiyuki author non-byline.; Yamashita Shizuya author non-byline.; Sairyo Masami author non-byline.; Nakagawa Yusuke author non-byline.; Nozaki Shuichi author non-byline.; Abe Haruhiko author non-byline.; Ueda Yasunori author non-byline.; Koretsune Yukihiro author non-byline.; Nagai Kunihiko author non-byline.; Yano Masamichi author non-byline.; Nishino Masami author non-byline.; Tanouchi Jun author non-byline.; Arita Yoh author non-byline.; Hasegawa Shinji author non-byline.; Ishizu Takamaru author non-byline.; Ichikawa Minoru author non-byline.; Takano Yuzuru author non-byline.; Rin Eisai author non-byline.; Watanabe Tetsuya author non-byline.; Hoshida Shiro author non-byline.; Izumi Masahiro author non-byline.; Yamamoto Hiroyoshi author non-byline.; Kato Hiroyasu author non-byline.; Nakatani Kazuhiro author non-byline.; Hiraoka Hisatoyo author non-byline.; Nishio Mayu author non-byline.; Hirooka Keiji author non-byline.; Yoshimura Takahiro author non-byline.; Yasuoka Yoshinori author non-byline.; Tani Akihiro author non-byline.; Okumoto Yasushi author non-byline.; Akagi Hideharu author non-byline.; Makino Yasunaka author non-byline.; Ohnishi Toshinari author non-byline.; Iwakura Katsuomi author non-byline.; Nishikawa Nagahiro author non-byline.; Kijima Yoshiyuki author non-byline.; Kitao Takashi author non-byline.; Kanai Hideyuki author non-byline.; Shioyama Wataru author non-byline.; Fujita Masashi author non-byline.; Harada Koichiro author non-byline.; Kumada Masahiro author non-byline.; Nakagawa Osamu author non-byline.; Araki Ryo author non-byline.; Yamada Takayuki author non-byline.; Maruyama Takao author non-byline.; Sera Fusako author non-byline.; Nakamoto Kei author non-byline.; Kioka Hidetaka author non-byline.; Ohtani Tomohito author non-byline.; Manabe Shirou author non-byline.;
• Is Part Of: BMJ open. Volume 10:Issue 10(2020)
• Publication Date: 2020-10-15
• Subjects: heart failure -- cardiology -- cardiac epidemiology; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2020-038294
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: Neither the pathophysiology nor an effective treatment for heart failure with preserved ejection fraction (HFpEF) has been elucidated to date. The purpose of this ongoing study is to elucidate the pathophysiology and prognostic factors for patients with HFpEF admitted to participating institutes. We also aim to obtain insights into the development of new diagnostic and treatment methods by analysing patient background factors, clinical data and follow-up information. Methods and analysis: This study is a prospective, multicentre, observational study of patients aged ≥20 years admitted due to acute decompensated heart failure with preserved left ventricular ejection fraction (≥50%) and elevated N-terminal-pro brain natriuretic peptide (NT-proBNP) (≥400 pg/mL). The study began in June 2016, with the participation of Osaka University Hospital and 31 affiliated facilities. We will collect data on history in detail, accompanying diseases, quality of life, frailty score, medication history, and laboratory and echocardiographic data. We will follow-up each patient for 5 years, and collect outcome data on mortality, cause of death, and the number and cause of hospitalisation. The target number of registered cases is 1500 cases in 5 years. Ethics and dissemination: The protocol was approved by the Institutional Review Board (IRB) of Osaka University Hospital on 24 February 2016 (ID: 15471), and by the IRBs of the all participating facilities. The findings will be disseminated through peer-reviewed publications and conference presentations.