TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9. Issue 1 (1st January 2019)

• Record Type: Journal Article
• Authors: Wang, Weimin; Li, Dan; Xiang, Liangliang; Lv, Mengying; Tao, Li; Ni, Tengyang; Deng, Jianliang; Gu, Xiancheng; Masatara, Sunagawa; Liu, Yanqing; Zhou, Yan
• Is Part Of: Cell adhesion & migration. Volume 13:Issue 1(2019)
• Page Start: 272
• Page End: 283
• Publication Date: 2019-01-01
• Subjects: CRC -- TIMP-2 -- MMP-9 -- prognosis -- metastasis; Cell adhesion -- Periodicals; Cell migration -- Periodicals; Cell interaction -- Periodicals; 574.876
• DOI: 10.1080/19336918.2019.1639303
• Languages: English
• ISSNs: 1933-6918

Abstract

ABSTRACT: Colorectal cancer has a common cause of morbidity and mortality. Therefore, it is urgent to detect reliable biomarkers to predict prognosis in CRC. Here, we determined the expression of TIMP-2 and MMP-9 in a CRC tissue microarray by immunohistochemistry. We found that lower TIMP-2 or/and higher MMP-9 expression in cancer tissues was correlated with poorer overall survival (OS). TIMP-2 or MMP-9 expression was independent prognostic factors for CRC. Furthermore, TIMP-2 and MMP-9 expression had a synergistic role as efficient prognostic indicators for CRC patients. In vitro and in vivo, TIMP-2 could inhibit HCT 116 cells invasion and migration by regulating MMP-9. In sum, a combined expression of TIMP-2 and MMP-9 as efficient prognostic indicators was found for the first time.