The Right Light: De Novo Design of a Robust Modular Photochemical Reactor for Optimum Batch and Flow Chemistry. Issue 1 (25th September 2019)

• Record Type: Journal Article
• Authors: Bonfield, Holly E.; Mercer, Kayleigh; Diaz‐Rodriguez, Alba; Cook, Gemma C.; McKay, Blandine S. J.; Slade, Pawel; Taylor, George M.; Ooi, Wei Xiang; Williams, Jason D.; Roberts, Jack P. M.; Murphy, John A.; Schmermund, Luca; Kroutil, Wolfgang; Mielke, Tamara; Cartwright, Jared; Grogan, Gideon; Edwards, Lee J.
• Is Part Of: ChemPhotoChem. Volume 4:Issue 1(2020)
• Page Start: 45
• Page End: 51
• Publication Date: 2019-09-25
• Subjects: cross-coupling reactions -- flow chemistry -- high-throughput screening -- photocatalysis; Photochemistry -- Periodicals; Periodicals; Electronic journals; 541.35
• DOI: 10.1002/cptc.201900203
• Languages: English
• ISSNs: 2367-0932

Abstract

Abstract: Having identified inconsistencies when repeating literature examples of photochemical transformations and difficulties recreating experimental setups, we devised several criteria that an ideal lab‐scale reactor should achieve. Herein, we introduce a versatile photoreactor for high‐throughput screening, preparative‐scale batch reactions and continuous processing, all with a single light source. The reactor utilizes interchangeable arrays of pseudo‐monochromatic high‐power LEDs in a range of synthetically useful wavelengths, combined with excellent temperature control. Moreover, light intensity can be modulated in an accurate and straightforward manner. This system has subsequently been tested on a range of literature methodologies. Abstract : The Right Light : A new commercial photoreactor was examined by performing several photochemical literature reactions. Our workflow is presented in the hope that others adopt the same methodology to begin the process of developing a standardized photochemical platform across academia and industry, that can be utilized by chemists to perform photochemistry in a high‐throughput manner whilst simultaneously developing the in‐depth reaction understanding required.