Multimodality Imaging Agents with PET as the Fundamental Pillar. Issue 9 (11th December 2018)

• Record Type: Journal Article
• Authors: Ni, Dalong; Ehlerding, Emily B.; Cai, Weibo
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 9(2019)
• Page Start: 2570
• Page End: 2579
• Publication Date: 2018-12-11
• Subjects: dual-modality imaging -- imaging agents -- multimodality imaging -- nanomedicine -- PET; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201806853
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Positron emission tomography (PET) provides quantitative information in vivo with ultra‐high sensitivity but is limited by its relatively low spatial resolution. Therefore, PET has been combined with other imaging modalities, and commercial systems such as PET/computed tomography (CT) and PET/magnetic resonance (MR) have become available. Inspired by the emerging field of nanomedicine, many PET‐based multimodality nanoparticle imaging agents have been developed in recent years. This Minireview highlights recent progress in the design of PET‐based multimodality imaging nanoprobes with an aim to overview the major advances and key challenges in this field and substantially improve our knowledge of this fertile research area. Abstract : Recent developments in multimodality imaging nanoprobes are systemically discussed in this Minireview, with a focus on the design of PET‐based dual‐ and higher‐modality imaging agents and their properties, biomedical applications, and significant clinical prospects.