Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. Issue 3 (17th March 2021)

• Record Type: Journal Article
• Authors: Setiabudi, Wega; Hungerford, Daniel; Subramaniam, Krishanthi; Vaselli, Natasha Marcella; Shaw, Victoria E; Wilton, Moon; Vivancos, Roberto; Aston, Stephen; Platt, Gareth; Moitt, Tracy; Jones, Ashley P; Gabbay, Mark; Buchan, Iain; Carrol, Enitan D; Iturriza-Gomara, Miren; Solomon, Tom; Greenhalf, William; Naisbitt, Dean J; Adams, Emily R; Cunliffe, Nigel A; Turtle, Lance; French, Neil
• Other Names: author non-byline.; Turtle Lance author non-byline.; Hungerford Daniel author non-byline.; Subramaniam Krishanthi author non-byline.; Vivancos Roberto author non-byline.; Gabbay Mark author non-byline.; Buchan Iain author non-byline.; Carrol Enitan D author non-byline.; Iturriza-Gomara Miren author non-byline.; Solomon Tom author non-byline.; Cunliffe Nigel A author non-byline.; Adams Emily R author non-byline.; Gamble Carrol author non-byline.; Crossley Lynnette author non-byline.; Joseph Neil author non-byline.; Setiabudi Wega author non-byline.; Vaselli Natasha Marcella author non-byline.; Wilton Moon author non-byline.; Troughton Lee D author non-byline.; Kilada Samantha author non-byline.; Abba Katharine author non-byline.; Simpson Victoria author non-byline.; Tulloch John S P author non-byline.; Goodwin Lynsey author non-byline.; Daws Rachael author non-byline.; Forootan Shiva S author non-byline.; Dobson Susan author non-byline.; Press Rachel author non-byline.; Spaine Vida author non-byline.; Hands Lesley author non-byline.; Bradfield Kate author non-byline.; McNally Carol author non-byline.; Moitt Tracy author non-byline.; Balabanova Silviya author non-byline.; Donohue Chloe author non-byline.; Finnetty Lynsey author non-byline.; Marsh Laura author non-byline.; Greenhalf William author non-byline.; Naisbitt Dean J author non-byline.; Shaw Victoria E author non-byline.; Aston Stephen author non-byline.; Platt Gareth author non-byline.; Thomson Paul J author non-byline.; Ogese Monday author non-byline.; Hammond Sean author non-byline.; Adair Kareena author non-byline.; Farrell Liam author non-byline.; Gardner Joshua author non-byline.; Jaruthamsophon Kanoot author non-byline.; Ali Serat-E author non-byline.; Lister Adam author non-byline.; Booth Laura author non-byline.; Ashworth Milton author non-byline.; Bullock Katie author non-byline.; Catterall Benjamin W A author non-byline.; Foster Terry author non-byline.; Lavelle-Langham Lara author non-byline.; Middleton Joanna author non-byline.; Reynolds William author non-byline.; Cass Emily author non-byline.; Carracedo Alejandra Doce author non-byline.; Davies Lianne author non-byline.; Flaherty Lisa author non-byline.; Oates Melanie author non-byline.; Maziere Nicole author non-byline.; Lloyd Jennifer author non-byline.; Jones Christopher author non-byline.; Massey Hannah author non-byline.; Holmes Anthony author non-byline.; Carlucci Nicola author non-byline.; Brammah Vanessa author non-byline.; Ramos Yasmyn author non-byline.; Allen Daniel author non-byline.; Armstrong Jane author non-byline.; Howarth Debbie author non-byline.; Wilcock Eve author non-byline.; Lowe Jena author non-byline.; Jones Jayne author non-byline.; Wright Paula author non-byline.; Slack Iain author non-byline.; McLaughlin Simone author non-byline.; Mason Jessica author non-byline.; Edwards Thomas author non-byline.; McKeown Claudia author non-byline.; Hendrick Elysse author non-byline.; Williams Chris author non-byline.; Byrne Rachel author non-byline.; Buist Kate author non-byline.; Garrod Gala author non-byline.; Owen Sophie author non-byline.; Jones Ashley P author non-byline.; Gkioni Efstathia author non-byline.; French Neil author non-byline.;
• Is Part Of: BMJ open. Volume 11:Issue 3(2021)
• Publication Date: 2021-03-17
• Subjects: COVID-19 -- immunology -- epidemiology -- respiratory infections -- virology; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2020-048317
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: The emergence and rapid spread of COVID-19 have caused widespread and catastrophic public health and economic impact, requiring governments to restrict societal activity to reduce the spread of the disease. The role of household transmission in the population spread of SARS-CoV-2, and of host immunity in limiting transmission, is poorly understood. This paper describes a protocol for a prospective observational study of a cohort of households in Liverpool City Region, UK, which addresses the transmission of SARS-CoV-2 between household members and how immunological response to the infection changes over time. Methods and analysis: Households in the Liverpool City Region, in which members have not previously tested positive for SARS-CoV-2 with a nucleic acid amplification test, are followed up for an initial period of 12 weeks. Participants are asked to provide weekly self-throat and nasal swabs and record their activity and presence of symptoms. Incidence of infection and household secondary attack rates of COVID-19 are measured. Transmission of SARS-CoV-2 will be investigated against a range of demographic and behavioural variables. Blood and faecal samples are collected at several time points to evaluate immune responses to SARS-CoV-2 infection and prevalence and risk factors for faecal shedding of SARS-CoV-2, respectively. Ethics and dissemination: The study has received approval from the National Health Service Research Ethics Committee; REC Reference: 20/HRA/2297, IRAS Number: 283 464. Results will be disseminated through scientific conferences and peer-reviewed open access publications. A report of the findings will also be shared with participants. The study will quantify the scale and determinants of household transmission of SARS-CoV-2. Additionally, immunological responses before and during the different stages of infection will be analysed, adding to the understanding of the range of immunological response by infection severity.