Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host. Issue 24 (6th December 2019)

• Record Type: Journal Article
• Authors: Hemmi, Silvio; Spindler, Katherine R.
• Is Part Of: FEBS letters. Volume 593:Issue 24(2019)
• Page Start: 3649
• Page End: 3659
• Publication Date: 2019-12-06
• Subjects: adenovirus vaccines -- adenovirus vectors -- alpha‐defensins -- host susceptibility to viruses -- immunoproteasome -- Ly6 -- mouse adenovirus -- PKR -- viral pathogenesis; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.13699
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Small laboratory animals are powerful models for investigating in vivo viral pathogenesis of a number of viruses. For adenoviruses (AdVs), however, species‐specificity poses limitations to studying human adenoviruses (HAdVs) in mice and other small laboratory animals. Thus, this review covers work on naturally occurring mouse AdVs, primarily mouse adenovirus type 1 (MAdV‐1), a member of the species Murine mastadenovirus A . Molecular genetics, virus life cycle, cell and tissue tropism, interactions with the host immune response, persistence, and host genetics of susceptibility are described. A brief discussion of MAdV‐2 (member of species Murine mastadenovirus B ) and MAdV‐3 (member of species Murine mastadenovirus C ) is included. We report the use of MAdVs in the development of vectors and vaccines.