Effects of biological sex on the pathophysiology of the heart. (13th January 2014)

• Record Type: Journal Article
• Authors: Fazal, Loubina; Azibani, Feriel; Vodovar, Nicolas; Cohen Solal, Alain; Delcayre, Claude; Samuel, Jane‐Lise
• Is Part Of: British journal of pharmacology. Volume 171:Number 3(2014:Feb.)
• Page Start: 555
• Page End: 566
• Publication Date: 2014-01-13
• Subjects: heart -- gender -- hypertrophy -- cardiac failure; Pharmacology -- Periodicals; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/bph.12279
• Languages: English
• ISSNs: 0007-1188

Abstract

Abstract : Cardiovascular diseases are the leading causes of death in men and women in industrialized countries. While the effects of biological sex on cardiovascular pathophysiology have long been known, the sex‐specific mechanisms mediating these processes have been further elucidated over recent years. This review aims at analysing the sex‐based differences in cardiac structure and function in adult mammals, and the sex‐based differences in the main molecular mechanisms involved in the response of the heart to pathological situations. It emerged from this review that the sex‐based difference is a variable that should be dealt with, not only in basic science or clinical research, but also with regards to therapeutic approaches. Linked Articles: This article is part of a themed section on Biological Sex and Cardiovascular Pharmacology. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐3