Hodgkin's lymphoma, nephrotic syndrome, and echinococcosis cysts: an unusual association and literature review. (2nd January 2019)

• Record Type: Journal Article
• Authors: Geylis, Michael; Rosen, Guy Beck; Danino, Dana; Schreiber, Ruth; Hassan, Dima; Nalbandyan, Karen; Nahum, Amit
• Is Part Of: Pediatric hematology and oncology. Volume 36:Number 1(2019)
• Page Start: 40
• Page End: 45
• Publication Date: 2019-01-02
• Subjects: Cystic echinococcosis -- nephrotic syndrome -- pediatric Hodgkin's lymphoma; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Hematologic Diseases -- Child; Hematologic Diseases -- Infant; Neoplasms -- Child; 618.9215
• DOI: 10.1080/08880018.2019.1571541
• Languages: English
• ISSNs: 0888-0018

Abstract

Abstract: We present a 5-year-old female with minimal change nephrotic syndrome (MCNS). Within several months, she became steroid-dependent with progression of edema and ascites. Imaging studies revealed abnormal solid mass and liver cysts and she was diagnosed with both abdominal Hodgkin's lymphoma (cHD) and large hepatic cystic echinococcosis (CE). Association between MCNS and cHL or with CE has been described in the literature in adults and rarely in the pediatric population. We report, for the first time, a simultaneous occurrence of all three: MCNS, cHL, and CE. Literature review and suggested pathophysiologic mechanisms underlying this phenomenon are presented.