Predictors of mortality and length of stay in patients with hospital-acquired Clostridioides difficile infection: a population-based study in Alberta, Canada. Issue 1 (September 2019)

• Record Type: Journal Article
• Authors: Leal, J.; Ronksley, P.; Henderson, E.A.; Conly, J.; Manns, B.
• Is Part Of: Journal of hospital infection. Volume 103:Issue 1(2019)
• Page Start: 85
• Page End: 91
• Publication Date: 2019-09
• Subjects: Clostridioides difficile -- Attributable mortality -- Epidemiology -- Length of stay; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2019.04.007
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: In a population-based, five-year retrospective cohort study of 5304 adult patients with hospital-acquired Clostridioides difficile infection across Alberta ( N =101 hospitals), 30-day all-cause and attributable mortality were 12.2% and 4.5%, respectively. Patients >75 years of age had the highest odds of attributable mortality (odds ratio (OR) 9.34, 95% confidence interval (CI) 2.92–29.83) and largest difference in mean length of stay (11.7 days, 95% CI 8.2–15.2). A novel finding was that elevated white blood cell count at admission was associated with reduced attributable mortality (OR 0.67, 95% CI 0.50–0.90) which deserves further study. Advancing age was incrementally and significantly associated with all outcomes.