A new baby in the c-Myc-directed transcriptional machinery: Che-1/AATF. Issue 11 (3rd June 2018)

• Record Type: Journal Article
• Authors: Folgiero, Valentina; Sorino, Cristina; Locatelli, Franco; Fanciulli, Maurizio
• Is Part Of: Cell cycle. Volume 17:Issue 11(2018)
• Page Start: 1286
• Page End: 1290
• Publication Date: 2018-06-03
• Subjects: Che-1 -- c-Myc -- BCP-ALL; Cell cycle -- Periodicals; 571.84377
• DOI: 10.1080/15384101.2018.1480227
• Languages: English
• ISSNs: 1538-4101

Abstract

ABSTRACT: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common malignancy in childhood. Despite the high cure-rate, identifying new druggable molecular targets is still of great interest. In a cohort of BCP-ALL pediatric patients, irrespectively of the molecule/karyotype lesions found, we recently observed high expression of c-Myc and Che-1/AATF, which disappears at time of remission. Study of the molecular mechanisms involved in this co-expression revealed that Che-1 expression was crucial for induction of blast-cell proliferation driven by c-Myc. Furthermore, Che-1/AATF silencing in primary BCP-ALL cell lines improves responsiveness to chemotherapy. These data individuate Che-1 as a possible novel target in the treatment of BCP-ALL able to affect c-Myc-driven tumorigenicity.