Oesophageal motor disorders and oesophageal endoscopic involvement in patients with systemic sclerosis: a systematic association?. (4th May 2021)

• Record Type: Journal Article
• Authors: Vitton, Véronique; Bazin, Camille; Luciano, Laure; Granel, Brigitte; Alessandrini, Marine; Harle, Jean-Robert
• Is Part Of: Scandinavian journal of gastroenterology. Volume 56:Number 5(2021)
• Page Start: 508
• Page End: 513
• Publication Date: 2021-05-04
• Subjects: Systemic sclerosis -- oesophagitis -- Barrett's oesophagus -- oesophageal high-resolution manometry; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.1080/00365521.2021.1881813
• Languages: English
• ISSNs: 0036-5521

Abstract

Abstract: Introduction: Although oesophageal motor disorders (OMDs) are frequent in systemic sclerosis (SSc), the frequency of associated endoscopic lesions is unknown. We aimed at assessing the presence of endoscopic lesions in SSc patients with OMD. The secondary objective was to identify the clinical and serological profile of such patients. Methods: This retrospective study included SSc patients suffering from OMD diagnosed by oesophageal high-resolution manometry (OHRM) and with recent upper gastro-intestinal endoscopy (UGIE). Clinical data collected were age, gender, body mass index, SSc disease duration, tobacco, SSc cutaneous type, non-digestive SSc visceral disorders, oesophageal symptoms, serological profile (autoantibodies), proton pump inhibitor use, time between SSc diagnosis and UGIE. Results: 53 selected patients from 210 SSc patients investigated by OHRM in our department were included. Among these patients, 25 (47.2%) had endoscopic lesions: 18 (34.6%) had oesophagitis and 7 (13.5%) had Barrett's oesophagus. The only two parameters significantly associated with endoscopic lesions were a shorter disease duration (6 vs. 11 years; p = .002) and a shorter delay between SSc diagnosis and UGIE (3 vs. 8.5 years; p = .002). No other clinical or biological parameters could help identify the patients at risk of endoscopic lesion. Conclusion: In our study, only a shorter disease duration and a shorter delay between SSc diagnosis and UGIE were significantly associated with the presence of endoscopic lesions in patients with OMD, but no other parameters were identified. This study highlights the need to perform UGIE in SSc patients with OMD whatever their clinical symptoms.