Modeling the probability of occurrence of events. (August 2021)

• Record Type: Journal Article
• Authors: Bottai, Matteo; Discacciati, Andrea; Santoni, Giola
• Is Part Of: Statistical methods in medical research. Volume 30:Number 8(2021)
• Page Start: 1976
• Page End: 1987
• Publication Date: 2021-08
• Subjects: Hazards -- rates -- survival analysis -- incidence -- probability; Medicine -- Research -- Statistical methods -- Periodicals; Research -- Periodicals; Review Literature -- Periodicals; Statistics -- methods -- Periodicals; Médecine -- Recherche -- Méthodes statistiques -- Périodiques; 610.727
• DOI: 10.1177/09622802211022403
• Languages: English
• ISSNs: 0962-2802

Abstract

This paper introduces the event-probability function, a measure of occurrence of an event of interest over time, defined as the instantaneous probability of an event at a given time point conditional on having survived until that point. Unlike the hazard function, the event-probability function is a proper probability. This paper describes properties and interpretation of the event-probability function, presents its connection with other popular functions, such as the hazard and survival functions, proposes practical flexible proportional-odds models for estimating conditional event-probabilities given covariates with possibly censored and truncated observations, discusses the theoretical and computational aspects of parameter estimation, and applies the proposed models for assessing mortality in patients with metastatic renal carcinoma from a randomized clinical trial.