Emotion introspection and regulation in depression. (30th July 2018)

• Record Type: Journal Article
• Authors: Herwig, Uwe; Opialla, Sarah; Cattapan, Katja; Wetter, Thomas C.; Jäncke, Lutz; Brühl, Annette B.
• Is Part Of: Psychiatry research. Volume 277(2018)
• Page Start: 7
• Page End: 13
• Publication Date: 2018-07-30
• Subjects: Cognitive control -- Amygdala -- Self-awareness -- Mindfulness -- Psychotherapy -- fMRI; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2018.04.008
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: Depressed patients are able to down-regulate amygdala through 'emo-spection'. Depression scores inversely correlate with prefrontal activity during 'emo-spection'. Self-reflection and 'emo-spection' are associated with increased M-/DLPFC activity. Abstract: Depressed patients suffer from an impairment to voluntarily influence and regulate their unpleasant emotional state. Strengthening the mental ability to interfere with dysfunctional emotion processing may be beneficial in treating depression. According to models of emotion processing this may be done by successful down-regulation of enhanced amygdala activity. We investigated short periods of intentional emotion-introspection compared with cognitive self-reflection as two domains of self-awareness in terms of effects on emotion regulation. Thirty depressed patients performed twelve second periods of emotion-introspection, self-reflection and a neutral condition during functional magnetic resonance imaging. We analyzed brain activation in the patients with depression by means of whole brain, region of interest and connectivity analyses. Amygdala activity decreased during emotion-introspection relative to self-reflection and to the neutral condition, whereby left amygdala was inversely activated relative to the left insula. Insula activity itself was correlated with medial and dorsolateral prefrontal cortex (PFC) activation. In conclusion, depressed patients are able to down-regulate amygdala activity by emotion-introspection. This may be interpreted as well-working emotion regulation supposedly induced by PFC connections mediated via insula. The finding supports the application of emotion-introspection, a mindfulness-related process, in a clinical setting as an element of psychotherapy to train and improve emotion regulation. Graphical Abstract: Image, graphical abstract