Proinflammatory Effects of C-Peptide in Different Tissues. (11th June 2012)

• Record Type: Journal Article
• Authors: Vasic, Dusica; Walcher, Daniel
• Other Names: Manabe Ichiro Academic Editor.
• Is Part Of: International journal of inflammation. Volume 2012(2012)
• Publication Date: 2012-06-11
• Subjects: Inflammation -- Periodicals; Inflammation; Inflammation; Periodicals; 617.22
• DOI: 10.1155/2012/932725
• Languages: English
• ISSNs: 2090-8040

Abstract

Abstract : Atherosclerosis is well known as an inflammatory disease that can lead to clinical complications such as heart attack or stroke. C-peptide as a cleavage product of proinsulin is in the last few decades known as an active peptide with a number of different effects on microvascular and macrovascular complications in type 2 diabetic patients. Patients with insulin resistance and early type 2 diabetes show elevated levels of C-peptide in blood. Several last findings demonstrated deposition of C-peptide in the vessel wall in ApoE-deficient mice and induction of local inflammation. Besides that, C-peptide has proliferative effects on human mesangial cells. This review discusses recently published proinflammatory effects of C-peptide in different tissues.