341 Diabetes Mellitus and Back Pain: Markers of Diabetes Disease Progression Are Associated With Chronic Back Pain. (1st August 2016)

• Record Type: Journal Article
• Authors: Rinaldo, Lorenzo; McCutcheon, Brandon A.; Gilder, Hannah; Kerezoudis, Panagiotis; Murphy, Meghan; Maloney, Patrick R.; Hassoon, Ahmed; Bydon, Mohamad
• Is Part Of: Neurosurgery. Volume 63:(2016)Supplement 1
• Page Start: 200
• Page End: 200
• Publication Date: 2016-08-01
• Subjects: Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1227/01.neu.0000489830.71012.d0
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: INTRODUCTION: Recent studies suggest that diabetic patients may be more likely to exhibit back pain. Correlating diabetic disease progression to the presence of back pain could provide insight into the relationship between these conditions. METHODS: A total of 67 132 patients within our institutional database were identified as having the diagnosis of either diabetes mellitus type I (DMI) or diabetes mellitus type II (DMII). Within this larger cohort, patients diagnosed with chronic back pain (CBP) were identified. In addition, patients with a history of spinal surgery were also identified. Clinical and laboratory measures of diabetic disease burden were then collected on all patients. Multinomial logistic regression analysis using a backward stepwise selection algorithm was then implemented for multivariable analysis to determine whether patient variables were associated with the diagnosis of CBP or history of spinal surgery among diabetic patients. RESULTS: On unadjusted analysis, highest recorded values of hemoglobin A1C (HgbA1C), low-density lipoprotein (LDL), triglycerides, and total cholesterol were significantly greater in diabetic patients with CPB and diabetic patients with CBP that underwent spinal surgery. Highest recorded value of high-density lipoprotein (HDL) was significantly lower in diabetic patients with CPB and diabetic patients with CBP that underwent spinal surgery. Highest recorded body mass index (BMI) was also greater in patients with CBP (36.67) and patients with CBP who underwent surgery (36.63) compared with patients without CBP (34.06, P < .001). On multinomial logistic regression analysis, increased age at time of DM diagnosis, increased duration of time with DM, presence of hypertension, presence of neuropathy, increased BMI, increased levels of HgbA1C, LDL, and triglycerides, and decreased levels of HDL were independently associated with the presence of CBP. CONCLUSION: Our results suggest that markers of diabetes disease progression are associated with the presence of back pain, suggesting that uncontrolled DM may be a contributing factor to the development of CBP.