Association of vitamin D with incident glaucoma: findings from the Women's Health Initiative. (11th January 2021)

• Record Type: Journal Article
• Authors: Carbone, Laura D; Johnson, Karen; Larson, Joseph C; Thomas, Fridtjof; Wactawski-Wende, Jean; Bollinger, Kathryn; Chen, Zhao; Watsky, Mitchell
• Is Part Of: Journal of investigative medicine. Volume 69:Number 4(2021)
• Page Start: 843
• Page End: 850
• Publication Date: 2021-01-11
• Subjects: vitamin D -- vitamin D deficiency -- blindness; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.1136/jim-2020-001645
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : The relationship between vitamin D and glaucoma is controversial. The objective of this study was to examine women from the Women's Health Initiative (WHI) to determine if there is an association between vitamin D and incident glaucoma in postmenopausal women. We examined the association between dietary vitamin D intake, vitamin D supplements and serum 25 hydroxyvitamin D (25(OH)D) levels and the risk of developing glaucoma. 143, 389 postmenopausal women from the WHI including a subset with serum 25(OH) D measurements were examined to determine the association of dietary, supplemental and serum levels of vitamin D to the development of glaucoma. Dietary intakes of vitamin D, use of vitamin D supplements and serum levels of 25(OH) D were predictors examined for the main outcome of incident glaucoma. In multivariable models adjusted for demographic, clinical variables and medication use, dietary vitamin D, vitamin D supplements, total vitamin D intake (diet plus supplements) and serum 25 (OH) D measurements were not significantly associated with incident glaucoma. In the CaD placebo-controlled intervention clinical trial, there was also no association in the active intervention arm with glaucoma. We conclude that dietary vitamin D intake, supplements and serum levels are not significantly related to the risk of developing glaucoma in postmenopausal women.