Acute Liver Failure Associated with Levetiracetam and Lacosamide Combination Treatment for Unspecified Epileptic Disorder. (19th August 2013)

• Record Type: Journal Article
• Authors: Gutiérrez-Grobe, Ylse; Bahena-Gonzalez, Jose Antonio; Herrera-Gomar, Magali; Mendoza-Diaz, Pedro; García-López, Sandra; González-Chon, Octavio
• Other Names: Alaghehbandan R. Academic Editor.; Lai C.-C. Academic Editor.; Mauritz W. Academic Editor.; Sand M. Academic Editor.
• Is Part Of: Case reports in emergency medicine. Volume 2013(2013)
• Publication Date: 2013-08-19
• Subjects: Emergency medicine -- Periodicals; Emergency Medicine; Emergency medicine; Periodicals; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.025
• DOI: 10.1155/2013/634174
• Languages: English
• ISSNs: 2090-648X

Abstract

Abstract : Background and Aim . Levetiracetam is a second-generation antiepileptic drug. It is approved as an adjunctive treatment of partial onset seizures with or without secondary generalization. It is considered safe with less than 1% of patients with transient elevations of liver enzymes. Methods . We report a case of acute liver failure secondary to Levetiracetam in combination with Lacosamide documented with a liver biopsy. Results . Liver biopsy demonstrated acute liver injury with a predominant submassive necrosis pattern and features of a drug-induced hepatitis. Conclusions . This is the first published case of acute liver failure due to antiepileptic therapy with Levetiracetam in combination with Lacosamide.