Successful Treatment of Fetal Intraperitoneal Administration of Immunoglobulin in a Case of Fetal Hemolytic Anemia with 131, 072-Fold Anti-E Alloimmunization. (17th November 2011)

• Record Type: Journal Article
• Authors: Yoshida, Masashi; Matsuda, Hideo; Hayata, Eijiro; Watanabe, Akio; Oeda, Miho; Furuya, Kenichi
• Other Names: Eichbaum M. H. Academic Editor.; Ezra Y. Academic Editor.
• Is Part Of: Case reports in obstetrics and gynecology. Volume 2011(2011)
• Publication Date: 2011-11-17
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; Obstetrics; Gynecology; Genital Diseases, Female; Generative organs, Female -- Diseases; Gynecology; Obstetrics; Electronic journals; Periodicals; Periodicals; 618
• DOI: 10.1155/2011/157510
• Languages: English
• ISSNs: 2090-6684

Abstract

Abstract : Object . We present here the case of severe fetal anemia caused by anti-E antibody positive, which showed a favorable course only with fetal intraperitoneal administration of immunoglobulin. Case . The mother was 31 years old, blood type B Rh : CCDee, gravida 1, with no history of transfusion. Anti-E antibody was detected in the maternal cross-match test at the 18th gestational week. In percutaneous umbilical blood sampling, the umbilical blood hemoglobin level was 9.1 g/dL and the result of the direct Coombs' test was positive at the 26th gestational week. Immunoglobulin injection into fetal abdominal cavity (IFAC) was administered a total 7 times. During the pregnancy, the indirect Coombs' test showed a 131, 072-fold increase. Conclusion . In this case, IFAC to block the reticuloendothelial system Fc receptor was successful. This procedure is promising as one of the treatment options for blood group incompatible pregnancy.