Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients. (11th September 2013)

• Record Type: Journal Article
• Authors: Beberashvili, Ilia; Sinuani, Inna; Azar, Ada; Kadoshi, Hadas; Shapiro, Gregory; Feldman, Leonid; Sandbank, Judith; Averbukh, Zhan
• Other Names: Seki George Academic Editor.
• Is Part Of: BioMed research international. Volume 2013(2013)
• Publication Date: 2013-09-11
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2013/796586
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Obestatin, a proposed anorexigenic gut hormone, has been shown to have a number of beneficial cardiotropic effects in experimental studies. We hypothesized that obestatin alteration in hemodialysis patients may link to clinical outcomes. This cross-sectional study with prospective followup for almost 4 years was performed on 94 prevalent hemodialysis patients. Obestatin, leptin, proinflammatory cytokines (tumor necrosis factor- α [TNF- α ], interleukin-6, and various nutritional markers were measured. Patients with low obestatin levels, defined as a level less than median, had a worse all-cause mortality and cardiovascular mortality. The crude all-cause (HR 2.23, 95% CI 1.17 to 4.24) and cardiovascular mortality hazard ratios (HR 4.03, 95% CI 1.27 to 12.76) in these patients continued to be significant after adjustment for various confounders for all-cause mortality. Across the four obestatin-TNF- α categories, the group with low obestatin and high TNF- α (above median level) exhibited a worse outcome in both all-cause mortality and cardiovascular mortality. Clinical characteristics of patients in low obestatin high TNF- α group did not differ from other obestatin-TNF- α categorized groups. In summary, low serum obestatin concentration is an independent predictor of mortality in prevalent hemodialysis patients. Novel interactions were observed between obestatin and TNF- α, which were associated with mortality risk, especially those due to cardiovascular causes.