A Case of Non-Small Cell Lung Cancer with Possible "Disease Flare" on Nivolumab Treatment. (27th December 2016)

• Record Type: Journal Article
• Authors: Chubachi, Shotaro; Yasuda, Hiroyuki; Irie, Hidehiro; Fukunaga, Koichi; Naoki, Katsuhiko; Soejima, Kenzo; Betsuyaku, Tomoko
• Other Names: Lenehan Peter F. Academic Editor.
• Is Part Of: Case reports in oncological medicine. Volume 2016(2016)
• Publication Date: 2016-12-27
• Subjects: Oncology -- Periodicals; Tumors -- Periodicals; Oncology -- Case studies -- Periodicals; Neoplasms; Oncology; Tumors; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.994
• DOI: 10.1155/2016/1075641
• Languages: English
• ISSNs: 2090-6706

Abstract

Abstract : Background . Recent clinical trials proven the clinically significant efficacy and tolerability of nivolumab, a programmed death 1 (PD-1) inhibitor, in previously treated patients with non-small cell lung cancer (NSCLC). Case Presentation . Here, we describe the case of a patient who experienced possible "disease flare" immediately after initiation of nivolumab treatment. A 54-year-old man was diagnosed with Stage IIB (T2N1M0) lung adenocarcinoma. After 7 years from recurrence, 10th line chemotherapy, nivolumab, was initiated. Six weeks later, after 3 cycles of nivolumab treatment, rapid lung cancer progression was observed with an increase in the size of the primary lesion, multiple novel nodules on both lungs, and multiple novel brain metastases. Conclusion . We believe that physicians should be made aware that, in a subset of NSCLC patients, disease flare might occur on nivolumab treatment.