Microalbuminuria and Glomerular Filtration Rate in Paediatric Visceral Leishmaniasis. (23rd June 2013)

• Record Type: Journal Article
• Authors: Verma, Neena; Lal, Chandra Shekhar; Rabidas, Vidyanand; Pandey, Krishna; Singh, Dharmendra; Kumar, Sanjay; Verma, Rakesh Bihari; Das, Pradeep
• Other Names: Babu Subash Academic Editor.
• Is Part Of: BioMed research international. Volume 2013(2013)
• Publication Date: 2013-06-23
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2013/498918
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Visceral leishmaniasis, caused by Leishmania donovani, is a serious form of leishmaniasis and fatal if untreated. Nearly half of the VL cases are children. There are very few studies of renal function in pediatric visceral leishmaniasis. The aim of this study was to evaluate renal dysfunction by studying glomerular filtration rate (GFR), microalbuminuria, and microscopic examination of urine. Laboratory analysis was performed on blood and urine samples of 40 parasitologically confirmed pediatric VL cases. Laboratory data of urine examination showed albuminuria in 10% (4/40), white blood cells in 20% (8/40), hematuria in 10% (4/40), microalbuminuria in 37.5% (15/40), and decreased GFR in 27.5% (11/40). Renal involvement was manifested in most of the pediatric VL cases. These findings may help clinicians in decision making for safe and suitable antileishmanial treatment particularly in childhood VL.