Secondary Hemophagocytic Syndrome Associated with Richter's Transformation in Chronic Lymphocytic Leukemia. (16th January 2014)

• Record Type: Journal Article
• Authors: El-Haj, Nura; Gonsalves, Wilson I.; Gupta, Vinay; Smeltzer, Jacob P.; Parikh, Sameer A.; Singh, Preet P.; Gangat, Naseema
• Other Names: Allsup D. J. Academic Editor.; Tauro S. Academic Editor.
• Is Part Of: Case reports in hematology. Volume 2014(2014)
• Publication Date: 2014-01-16
• Subjects: Hematology -- Periodicals; Hematology -- Case studies -- Periodicals; Blood -- Diseases -- Periodicals; Hematology; Hematologic Diseases; Blood -- Diseases; Hematology; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.15
• DOI: 10.1155/2014/287479
• Languages: English
• ISSNs: 2090-6560

Abstract

Abstract : Hemophagocytic syndrome (HPS) is an extremely rare condition arising from the overactivation of one's own immune system. It results in excessive inflammation and tissue destruction. Prompt initiation of treatment is warranted in either scenario in order to decrease mortality. Most cases are triggered by infectious agents, malignancy, or drugs. We describe the first case of a CLL patient presenting with HPS due to acquisition of EBV-related large cell lymphoma in the setting of profound immunodeficiency.