Topical Promethazine Side Effects: Our Experience and Review of the Literature. (19th November 2013)

• Record Type: Journal Article
• Authors: Cantisani, C.; Ricci, S.; Grieco, T.; Paolino, G.; Faina, V.; Silvestri, E.; Calvieri, S.
• Other Names: Baynes Ronald E. Academic Editor.
• Is Part Of: BioMed research international. Volume 2013(2013)
• Publication Date: 2013-11-19
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2013/151509
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Promethazine hydrochloride is a first-generation H1 receptor antagonist, antihistamine, and antiemetic medication that can also have strong sedative effects. The apparent ability of topical H1r/2r antagonists to target epidermal H1/2r was translated into increased efficacy in the treatment of inflammatory dermatoses, likely due to decreased inflammation and enhanced barrier function.