Multiple Cutaneous Angiosarcomas after Breast Conserving Surgery and Bilateral Adjuvant Radiotherapy: An Unusual Case and Review of the Literature. (5th March 2014)

• Record Type: Journal Article
• Authors: Meattini, Icro; Santi, Raffaella; Scartoni, Daniele; Giacomelli, Irene; De Luca Cardillo, Carla; Scotti, Vieri; Casella, Donato; Simoncini, Roberta; Orzalesi, Lorenzo; Nori, Jacopo; Paglierani, Milena; Livi, Lorenzo
• Other Names: Aksoy S. Academic Editor.; Buchanich J. M. Academic Editor.; Lu L. Academic Editor.
• Is Part Of: Case reports in oncological medicine. Volume 2014(2014)
• Publication Date: 2014-03-05
• Subjects: Oncology -- Periodicals; Tumors -- Periodicals; Oncology -- Case studies -- Periodicals; Neoplasms; Oncology; Tumors; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.994
• DOI: 10.1155/2014/413030
• Languages: English
• ISSNs: 2090-6706

Abstract

Abstract : Breast angiosarcomas (BAs) are rare but serious events that may arise after radiation exposure. Disease outcome is poor, with high risk of local and distant failure. Recurrences are frequent also after resection with negative margins. The spectrum of vascular proliferations associated with radiotherapy in the setting of breast cancer has expanded, including radiation-associated atypical vascular lesions (AVLs) of the breast skin as a rare, but well-recognized, entity. Although pursuing a benign behavior, AVLs have been regarded as possible precursors of postradiation BAs. We report an unusual case of a 71-year-old woman affected by well-differentiated bilateral cutaneous BA, diagnosed 1.9 years after adjuvant RT for synchronous bilateral breast cancer. Whole-life clinical followup is of crucial importance in breast cancer patients.