Synthesis, Solution, and Structural Characterization of Tetrahydrofuranyl-2, 2-Bisphosphonic Acid Disodium Salt. (11th May 2010)

• Record Type: Journal Article
• Authors: Maltezou, Elena; Stylianou, Marios; Roy, Sudeshna; Drouza, Chryssoula; Keramidas, Anastasios D.
• Other Names: Perlepes Spyros Academic Editor.
• Is Part Of: Bioinorganic chemistry and applications. Volume 2010(2010)
• Publication Date: 2010-05-11
• Subjects: Bioinorganic chemistry -- Periodicals; Bioinorganic chemistry; Biochemistry; Inorganic Chemistry; Chemistry, Bioinorganic; Periodicals; 572.51
• DOI: 10.1155/2010/563875
• Languages: English
• ISSNs: 1565-3633

Abstract

Abstract : Bisphosphonates are biologically relevant therapeutics for bone disorders and cancer. Reaction of γ -chlorobutyric acid, phosphorus acid, and phosphorus trichloride without the use of solvent gave the tetrahydrofuranyl-2, 2-bisphosphonate sodium salt (N a 2 H 2 L ). The N a 2 H 2 L was isolated, characterized in solution by H, C, and P NMR spectroscopy and in solid state by single X-Ray crystallography. The crystal structure showed that the N a 2 H 2 L forms in the crystal infinite two-dimensional sheets stacked one parallel to the other. A comparison of the chelating properties of H 2 L 2 − with similar hydroxyl bisphosphonate ligands shows that the strength of the Na–O(furanyl/hydroxyl) bond is directly related to the total charge of the ligand anion.