Fatal Disseminated Fusarium Infection in a Human Immunodeficiency Virus Positive Patient. (13th May 2013)

• Record Type: Journal Article
• Authors: Esnakula, Ashwini K.; Summers, Irorere; Naab, Tammey J.
• Other Names: Ghate M. Academic Editor.; Horrocks P. Academic Editor.; Stringer E. M. Academic Editor.
• Is Part Of: Case reports in infectious diseases. Volume 2013(2013)
• Publication Date: 2013-05-13
• Subjects: Communicable diseases -- Periodicals; Communicable diseases -- Case studies -- Periodicals; Communicable Diseases; Infectious Disease Medicine; Communicable diseases; Electronic journals; Periodicals; Case studies; Periodicals; 616.9
• DOI: 10.1155/2013/379320
• Languages: English
• ISSNs: 2090-6625

Abstract

Abstract : Systemic mycotic infections have been increasing in incidence in immunocompromised patients. Although yeasts are most often isolated, opportunistic fungal infections may also be caused by filamentous fungi, including Aspergillus and Fusarium . Like Aspergillus, Fusarium is angioinvasive with an ability to disseminate widely. Disseminated fusariosis is most commonly linked to prolonged neutropenia. Disseminated infections due to Fusarium are rare in Human Immunodeficiency Virus (HIV) positive patients but have been reported in HIV positive patients with neutropenia and lymphoma. We describe an HIV positive patient without neutropenia, skin lesions, or concomitant malignancy, who developed fatal disseminated infection with possible endocarditis due to Fusarium solani . Early identification of Fusarium is important because of its high level of resistance to several antifungal drugs, with response often requiring combination therapy.