Pre‐procedure intravenous lidocaine administration on propofol consumption for endoscopic retrograde cholangiopancreatography: A prospective, randomized, double‐blind study. Issue 5 (13th December 2020)

• Record Type: Journal Article
• Authors: Ates, Irem; Aydin, Muhammed Enes; Albayrak, Bulent; Disci, Esra; Ahiskalioglu, Elif Oral; Celik, Erkan Cem; Baran, Onur; Ahiskalioglu, Ali
• Is Part Of: Journal of gastroenterology and hepatology. Volume 36:Issue 5(2021)
• Page Start: 1286
• Page End: 1290
• Publication Date: 2020-12-13
• Subjects: Endoscopic retrograde cholangiopancreatography -- Intravenous lidocaine -- Propofol -- Sedation; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.15356
• Languages: English
• ISSNs: 0815-9319

Abstract

Abstract: Background and Aim: The endoscopic retrograde cholangiopancreatography (ERCP) procedure is generally performed in patients with high comorbidity. We aimed to reduce the consumption of propofol by adding lidocaine before ERCP. Methods: Eighty ERCP patients with ASA I–III, aged between 45–75 years, were randomly divided into two groups. Lidocaine group (group L, n = 40), received 1‐mg midazolam, 1.5 mg/kg lidocaine, and 1 mg/kg propofol intravenously. The control group (group C, n = 40) received 1‐mg midazolam, saline in the same volume as the lidocaine group, and 1 mg/kg propofol intravenously. Propofol was administered with intermittent bolus doses. Propofol consumption, oropharyngeal reflex, recovery time, endoscopist satisfaction, ketamine need, and side‐effects were recorded. Results: Propofol consumption during the procedure was statistically lower in group L than in the control group (157.25 ± 39.16 mg vs 228.75 ± 64.62 mg respectively, P < 0.001). Additionally, recovery time was statistically faster in group L compared with the control group (7.78 ± 3.95 min vs 11.92 ± 3.24 min respectively, P < 0.001). The oropharyngeal reflex was less in group L than control group (6/40 vs 15/40 respectively, P = 0.042). There was no significant difference between the two groups regarding visual analogue scale scores and endoscopist satisfaction ( P > 0.05). Conclusions: We recommend the use of intravenous lidocaine before the ERCP procedure as it reduces propofol consumption, recovery times, and oropharyngeal reflex.