Renal denervation for the treatment of ventricular arrhythmias: A systematic review and meta‐analysis. (16th April 2021)

• Record Type: Journal Article
• Authors: Prado, Gabriela M.; Mahfoud, Felix; Lopes, Renato D.; Moreira, Dalmo A. R.; Staico, Rodolfo; Damiani, Lucas P.; Ukena, Christian; Armaganijan, Luciana V.
• Is Part Of: Journal of cardiovascular electrophysiology. Volume 32:Number 5(2021)
• Page Start: 1430
• Page End: 1439
• Publication Date: 2021-04-16
• Subjects: antitachycardia pacing -- ICD shocks -- implantable cardioverter–defibrillator -- renal denervation -- ventricular arrhythmias; Blood vessels -- Physiology -- Periodicals; Electrophysiology -- Periodicals; Heart -- Physiology -- Periodicals; 612.1
• DOI: 10.1111/jce.15004
• Languages: English
• ISSNs: 1045-3873

Abstract

Abstract: Introduction: Ventricular arrhythmias (VAs) are a major cause of morbidity and mortality in patients with heart disease. Recent studies evaluated the effect of renal denervation (RDN) on the occurrence of VAs. We conducted a systematic review and meta‐analysis to determine the efficacy and safety of this procedure. Methods and Results: A systematic search of the literature was performed to identify studies that evaluated the use of RDN for the management of VAs. Primary outcomes were reduction in the number of VAs and implantable cardioverter–defibrillator (ICD) therapies. Secondary outcomes were changes in blood pressure and renal function. Ten studies (152 patients) were included in the meta‐analysis. RDN was associated with a reduction in the number of VAs, antitachycardia pacing, ICD shocks, and overall ICD therapies of 3.53 events/patient/month (95% confidence interval [CI] = −5.48 to −1.57), 2.86 events/patient/month (95% CI = −4.09 to −1.63), 2.04 events/patient/month (95% CI = −2.12 to −1.97), and 2.68 events/patient/month (95% CI = −3.58 to −1.78), respectively. Periprocedural adverse events occurred in 1.23% of patients and no significant changes were seen in blood pressure or renal function. Conclusions: In patients with refractory VAs, RDN was associated with a reduction in the number of VAs and ICD therapies, and was shown to be a safe procedure.