Minimalist Tissue Engineering Approaches Using Low Material‐Based Bioengineered Systems. Issue 9 (11th March 2021)

• Record Type: Journal Article
• Authors: Correia, Clara R.; Bjørge, Isabel M.; Nadine, Sara; Mano, João F.
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 9(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-11
• Subjects: low‐material based strategies -- self‐organization -- tissue healing; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202002110
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: From an "over‐engineering" era in which biomaterials played a central role, now it is observed to the emergence of "developmental" tissue engineering (TE) strategies which rely on an integrative cell‐material perspective that paves the way for cell self‐organization. The current challenge is to engineer the microenvironment without hampering the spontaneous collective arrangement ability of cells, while simultaneously providing biochemical, geometrical, and biophysical cues that positively influence tissue healing. These efforts have resulted in the development of low‐material based TE strategies focused on minimizing the amount of biomaterial provided to the living key players of the regenerative process. Through a "minimalist‐engineering" approach, the main idea is to fine‐tune the spatial balance occupied by the inanimate region of the regenerative niche toward maximum actuation of the key living components during the healing process. Abstract : The concept of minimalistic‐engineering approaches relies on integrative cell‐material strategies that recognize the power of cells to self‐organize during tissue healing. In particular, low‐material based tissue engineering strategies that fine‐tune the spatial balance occupied by the inanimate region of the regenerative niche towards maximum actuation of key living components are herein highlighted.