A microfluidic dosimetry cell to irradiate solutions with poorly penetrating radiations: a step towards online dosimetry for synchrotron beamlines. (2nd May 2021)

• Record Type: Journal Article
• Authors: Huart, Lucie; Nicolas, Christophe; Hervé du Penhoat, Marie-Anne; Guigner, Jean-Michel; Gosse, Charlie; Palaudoux, Jérôme; Lefrançois, Stephane; Mercere, Pascal; Dasilva, Paulo; Renault, Jean-Philippe; Chevallard, Corinne
• Is Part Of: Journal of synchrotron radiation. Volume 28:Part 3(2021)
• Page Start: 778
• Page End: 789
• Publication Date: 2021-05-02
• Subjects: water radiolysis -- dosimetry -- soft X‐rays -- microfluidics; Synchrotron radiation -- Periodicals; Free electron lasers -- Periodicals; 539.73505
• DOI: 10.1107/S1600577521002691
• Languages: English
• ISSNs: 0909-0495

Abstract

Abstract : The application of a microfluidic cell, specifically optimized for low penetrating soft X‐ray radiation, as a dosimetry cell is reported. An analysis of the important parameters of the microfluidic cell, as well as their influences over dosimetry, is also reported. Measurements at 1.28 keV led to the determination of a hydroxyl production yield, G (HO . ), of 0.025 ± 0.004 µmol J −1 . Abstract : Synchrotron radiation can induce sample damage, whether intended or not. In the case of sensitive samples, such as biological ones, modifications can be significant. To understand and predict the effects due to exposure, it is necessary to know the ionizing radiation dose deposited in the sample. In the case of aqueous samples, deleterious effects are mostly induced by the production of reactive oxygen species via water radiolysis. These species are therefore good indicators of the dose. Here the application of a microfluidic cell specifically optimized for low penetrating soft X‐ray radiation is reported. Sodium benzoate was used as a fluorescent dosimeter thanks to its specific detection of hydroxyl radicals, a radiolytic product of water. Measurements at 1.28 keV led to the determination of a hydroxyl production yield, G (HO . ), of 0.025 ± 0.004 µmol J −1 . This result is in agreement with the literature and confirms the high linear energy transfer behavior of soft X‐rays. An analysis of the important parameters of the microfluidic dosimetry cell, as well as their influences over dosimetry, is also reported.