SNHG12 promotes carcinogenesis of human renal cell cancer via functioning as a competing endogenous RNA and sponging miR‐30a‐3p. Issue 10 (30th March 2021)

• Record Type: Journal Article
• Authors: Yu, Hongyuan; Liu, Junlong; Zhang, Zhe; Zhu, Yuyan; Bi, Jianbin; Kong, Chuize
• Is Part Of: Journal of cellular and molecular medicine. Volume 25:Issue 10(2021)
• Page Start: 4696
• Page End: 4708
• Publication Date: 2021-03-30
• Subjects: competing endogenous RNA -- miR‐30a‐3p -- renal cell carcinoma -- small nucleolar RNA host gene 12; Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.16417
• Languages: English
• ISSNs: 1582-1838

Abstract

Abstract: Small nucleolar RNA host gene 12 (SNHG12) has been indicated in the tumorigenesis of various human cancers, including clear cell renal cell carcinoma (ccRCC). However, the underlying mechanisms of SNHG12 driving progression of ccRCC remain incompletely understood. In the present study, we discovered that SNHG12 is up‐regulated in ccRCC and that overexpression of SNHG12 predicted poor clinical outcome of ccRCC patients. SNHG12 knockdown notably inhibited proliferation and migration of RCC cells. Furthermore, we discovered that miR‐30a‐3p, a putative ccRCC inhibitor, was competitively sponged by SNHG12. Via the crosstalk network, SNHG12 was capable of up‐regulating multiple target genes of miR‐30a‐3p, namely, RUNX2, WNT2 and IGF‐1R, which have been identified to facilitate tumorigenesis of ccRCC. Taken together, our present study suggested a novel ceRNA network, in which SNHG12 could promote the malignancy of ccRCC although competitively binding with miR‐30a‐3p and consequently release the expression of its downstream cancer‐related genes.