Targeted Chemotherapy: Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump (Adv. Mater. Technol. 5/2021). Issue 5 (5th May 2021)

• Record Type: Journal Article
• Authors: Waldherr, Linda; Seitanidou, Maria; Jakešová, Marie; Handl, Verena; Honeder, Sophie; Nowakowska, Marta; Tomin, Tamara; Karami Rad, Meysam; Schmidt, Tony; Distl, Joachim; Birner‐Gruenberger, Ruth; von Campe, Gord; Schäfer, Ute; Berggren, Magnus; Rinner, Beate; Asslaber, Martin; Ghaffari‐Tabrizi‐Wizsy, Nassim; Patz, Silke; Simon, Daniel T.; Schindl, Rainer
• Is Part Of: Advanced materials technologies. Volume 6:Issue 5(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-05
• Subjects: electrophoretic drug delivery -- gemcitabine -- glioblastoma multiforme -- organic electronic ion pumps; Materials science -- Periodicals; Technological innovations -- Periodicals; Materials science; Technological innovations; Periodicals; 620.1105
• DOI: 10.1002/admt.202170026
• Languages: English
• ISSNs: 2365-709X

Abstract

Abstract : In article number 2001302, Silke Patz, Daniel T. Simon, Rainer Schindl, and co‐workers engineer an electronically‐driven ion pump for the targeted delivery of the charged chemotherapeutic gemcitabine to brain cancer cells. By delivering drug ions over a cation exchange membrane at currents in the nanoampere range, brain cancer cell death and microtumor disintegration is triggered. This local gemcitabine treatment offers a therapeutical window, in contrast to standard treatment.