MMP9‐Responsive Peptides: Matrix Metalloproteinase‐9‐Responsive Surface Charge‐Reversible Nanocarrier to Enhance Endocytosis as Efficient Targeted Delivery System for Cancer Diagnosis and Therapy (Adv. Healthcare Mater. 9/2021). Issue 9 (5th May 2021)

• Record Type: Journal Article
• Authors: Han, Qiu‐Ju; Lan, Xiao‐Tong; Wen, Ying; Zhang, Chuan‐Zeng; Cleary, Michael; Sayyed, Yasra; Huang, Guangdong; Tuo, Xiaoling; Yi, Long; Xi, Zhen; Li, Lu‐Yuan; Zhang, Qiang‐Zhe
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 9(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-05
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202170047
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : In article number 2002143 by Qiang‐Zhe Zhang, Lu‐Yuan Li, and co‐workers, a novel MMP9‐catalyzed charge reversal nanoparticle (O‐NP) is developed for theranostic agents in cancer diagnosis and therapy. The O‐NP nanohybrid successfully performs preferential accumulation and enhances the endocytosis in MMP9‐expressing xenografted tumors by charge reversal from negative to positive in mouse models, which improves the sensitivity of diagnosis agents and the anti‐tumor effects of drugs in vivo by overcoming their low solubility and/or nonspecific enrichment.