Front Cover: Transmembrane Transport of Bicarbonate Unravelled (Chem. Eur. J. 26/2021). Issue 26 (28th April 2021)

• Record Type: Journal Article
• Authors: Martínez‐Crespo, Luis; Hewitt, Sarah H.; De Simone, Nicola Alessandro; Šindelář, Vladimír; Davis, Anthony P.; Butler, Stephen; Valkenier, Hennie
• Is Part Of: Chemistry. Volume 27:Issue 26(2021)
• Page Start: 7315
• Page End: 7315
• Publication Date: 2021-04-28
• Subjects: bicarbonate -- fluorescent probes -- ion transport -- membranes -- supramolecular chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202101358
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : The development of synthetic bicarbonate transporters is of high interest for potential therapeutic applications. This work presents a new assay to study bicarbonate transport, based on a europium complex that is encapsulated inside liposomes and reports changes in the intravesicular concentration of bicarbonate in a direct and highly sensitive way. The assay revealed that transporters can act via different mechanisms, involving actual transport of HCO3 − anions or passive diffusion of CO2 . More information can be found in the Full Paper by S. Butler, H. Valkenier, et al. (DOI: 10.1002/chem.202100491 ).