An Investigation into the Intrinsic Peroxidase‐Like Activity of Fe‐MOFs and Fe‐MOFs/Polymer Composites. Issue 5 (24th March 2021)

• Record Type: Journal Article
• Authors: Thakur, Bhawana; Karve, Vikram V.; Sun, Daniel T.; Semrau, A. Lisa; Weiß, Lennart J. K.; Grob, Leroy; Fischer, Roland A.; Queen, Wendy L.; Wolfrum, Bernhard
• Is Part Of: Advanced materials technologies. Volume 6:Issue 5(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-24
• Subjects: conducting polymers -- H 2O 2 sensors -- metal organic frameworks -- peroxidase‐like activity -- polymer composites of metal organic frameworks; Materials science -- Periodicals; Technological innovations -- Periodicals; Materials science; Technological innovations; Periodicals; 620.1105
• DOI: 10.1002/admt.202001048
• Languages: English
• ISSNs: 2365-709X

Abstract

Abstract: The quest for developing materials that provide a perfect trade‐off between factors such as enzyme‐like response, stability, and low cost has been a long‐standing challenge in the field of biosensing. Metal‐organic frameworks (MOFs) and their composites have emerged as promising candidates for biosensing applications due to their exceptional properties such as tunable pore size, high specific surface area, and exposed active sites. A comparative study of the intrinsic peroxidase‐like activity of five different MOF materials: Fe‐BTC, NH2 ‐MIL‐101(Fe), composites of Fe‐BTC with polymers polydopamine (PDA), poly p‐phenylenediamine (PpPDA), and poly(3, 4‐ethylenedioxythiophene) is reported for the detection of H2 O2, an important biomarker in biomedical diagnostics. The response of these materials toward H2 O2 via electrochemical and colorimetric techniques is mapped and it is found that, at neutral pH, the Fe‐BTC/PEDOT composite exhibits the highest sensitivity and activity compared to other MOF materials in this study. The results indicate that the combination of unique properties of Fe‐BTC and conducting polymer PEDOT, improves the peroxidase‐like activity of the Fe‐BTC/PEDOT composite compared to the individual components. This work presents a new opportunity for easy‐to synthesize and low‐cost MOFs/conducting polymer composites for biosensing applications and provides significant insights to achieve rational design of composites with desirable functional properties Abstract : Intrinsic peroxidase‐like activity of five different Fe‐MOFs and Fe‐MOFs/polymer composites is investigated via electrochemical and colorimetric techniques. Experiments reveal that the incorporation of conducting polymer PEDOT within the pores of Fe‐BTC enhances the intrinsic peroxidase‐like activity of the resulting composite. The work is a step toward unleashing the full potential of Fe‐MOFs/polymer composites for biosensing application.