Impact of sex on outcomes after percutaneous repair of functional mitral valve regurgitation. Issue 6 (22nd February 2021)

• Record Type: Journal Article
• Authors: Chan, Vincent; Messika‐Zeitoun, David; Labinaz, Marino; Hynes, Mark; Nicholson, Donna; Dryden, Adam; Mesana, Thierry; Hibbert, Benjamin
• Is Part Of: Journal of cardiac surgery. Volume 36:Issue 6(2021)
• Page Start: 1900
• Page End: 1903
• Publication Date: 2021-02-22
• Subjects: Heart -- Surgery -- Periodicals; 617.412005
• DOI: 10.1111/jocs.15445
• Languages: English
• ISSNs: 0886-0440

Abstract

Abstract: Background: The role of percutaneous repair of functional mitral regurgitation (MR) is evolving. Left ventricle remodeling is known to be different between men and women; however, outcomes following percutaneous repair of functional MR have not considered the impact of sex. Methods: Between 2012 and 2018, 175 patients underwent percutaneous repair of functional MR with the Mitra Clip NT/NTR (Abbott) at our institution. Patients were assessed in a dedicated clinic with a follow‐up that averaged 0.7 ± 1.2 years and extended to 5.7 years. Results: Men had a larger body surface area than women ( p < .001), and were more likely than women to have diabetes preoperatively ( p = .02). There were no deaths or instances of single leaflet detachment. Immediate postprocedure MR was ≤2+ in 158 (90%) with a mean trans‐mitral valve repair gradient of 3.4 ± 1.0 and 3.5 ± 2.1 mmHg, respectively for women and men ( p = .8). One‐ and 2‐year freedom from MR ≥3+ was 86.0 ± 3.5% and 77.6 ± 5.1%, respectively. After adjusting for differences between male and female patients, women were more likely to have recurrent MR ≥3+ (hazard ratio, 4.7; 95% confidence interval, 1.2–18.4; p = .03). Upon adjusted analysis, there was also no association between gender and survival ( p = .2). One‐ and 2‐year survival was 69.8 ± 4.3% and 54.3 ± 5.5%, respectively. Conclusion: Women are more likely to have recurrent severe MR after percutaneous repair of functional MR. The mechanism for this remains undetermined.