How do you mend inactive tumor suppressor mutants? You glue them!. Issue 5 (20th May 2021)

• Record Type: Journal Article
• Authors: Hata, Akiko; Lagna, Giorgio
• Is Part Of: Cell chemical biology. Volume 28:Issue 5(2021)
• Page Start: 585
• Page End: 587
• Publication Date: 2021-05-20
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2021.04.023
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : SMAD4 mutations that disrupt its interaction with SMAD3 and attenuate tumor suppression by TGF-β are major oncogenic drivers. Tang et al. (2020) report the discovery of small molecules that restore the SMAD4:SMAD3 complex and its cytostatic activity, exemplifying the therapeutic potential of fixing tumor suppressor mutants using molecular glues. Abstract : SMAD4 mutations that disrupt its interaction with SMAD3 and attenuate tumor suppression by TGF-β are major oncogenic drivers. Tang et al. report the discovery of small molecules that restore the SMAD4:SMAD3 complex and its cytostatic activity, exemplifying the therapeutic potential of fixing tumor suppressor mutants using molecular glues.