Strategies to load therapeutics into polysaccharide-based nanogels with a focus on microfluidics: A review. (15th August 2021)

• Record Type: Journal Article
• Authors: Zoratto, N.; Montanari, E.; Viola, M.; Wang, J.; Coviello, T.; Di Meo, C.; Matricardi, P.
• Is Part Of: Carbohydrate polymers. Volume 266(2021)
• Publication Date: 2021-08-15
• Subjects: AA asiatic acid -- Alg alginate -- Alg-CHO aldehyde-functionalized alginate -- Alg-PDEA alginate-poly(2-(diethylamino)ethyl methacrylate) -- ALN alendronate -- AmPs antimicrobial peptides -- APCs antigen-presenting cells -- BoHc/A botulinum type-A neurotoxin subunit antigen Hc -- BSA bovine serum albumin -- CDDP cisplatin-based HA nanocomplexes -- CDs cyclodextrins -- CMD-SS-LCA carboxymethyl dextran-lithocholic acid -- Cs chitosan -- CSLNs cationic solid lipid nanoparticles -- DA desoxycholic acid -- DCs dendritic cells -- DD deacetylation degree -- DEAE diethyl amino ethyl amine -- DEX dexamethasone -- Dex dextran -- DHA 1, 4-dihydroxyanthraquinone -- DOX doxorubicin -- DSB di-strylbenzene derivative -- dsDNA double-stranded DNA -- E.E. encapsulation efficiency percentage -- FA folic acid -- FNC flash nanocomplexation -- Gel gellan -- Gel-Ch gellan-cholesterol -- Gel-Rfv gellan-riboflavin -- GSH glutathione -- HA hyaluronic acid -- HA-AT thiolated alkyl derivative of hyaluronic acid -- HA-APBA hyaluronan‑boronic acid -- HA-Ch hyaluronan-cholesterol -- HA-Rfv hyaluronan-riboflavin -- HBsAg surface protein of Hepatitis B virus -- HCPT hydroxycamptothecin -- IDA iminodiacetic acid -- MA malonic acid -- Man mannan -- MIC minimum inhibitory concentration -- miRNA microRNA -- MIVM multi-inlet vortex mixer -- mRNA messenger RNA -- MW molecular weight -- NGs nanogels -- OVA ovalbumin -- PDI polydispersity index -- pDNA plasmid DNA -- PAA poly(acrylicacid) -- PEI polyethylenimine -- PEG polyethylene glycol -- PIR piroxicam -- PPZ perphenazine -- PTX paclitaxel -- Pul pullulan -- Pul-Ch pullulan-cholesterol -- pβ-CD poly-β-cyclodextrin -- RA retinoic acid -- RGD Arg-Gly-Asp -- rHBsAg recombinant hepatitis B surface antigen -- siRNA short interfering RNA -- SODB1 superoxide dismutase -- SpAcDEX spermine-modified acetalated dextran -- ssDNA single-strended DNA -- TA tannic acid -- TOPSi thermally oxidized porous silicon particles -- TPP pentasodium triphosphate -- TT tetanus taxoid; Nanogels -- Polysaccharides -- Drug loading methods -- Microfluidics -- Nanogels-based vaccines; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118119
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Nowadays nanoparticles are increasingly investigated for the targeted and controlled delivery of therapeutics, as suggested by the high number of research articles (2400 in 2000 vs 8500 in 2020). Among them, almost 2% investigated nanogels in 2020. Nanogels or nanohydrogels (NGs) are nanoparticles formed by a swollen three-dimensional network of synthetic polymers or natural macromolecules such as polysaccharides. NGs represent a highly versatile nanocarrier, able to deliver a number of therapeutics. Currently, NGs are undergoing clinical trials for the delivery of anti-cancer vaccines. Herein, the strategies to load low molecular weight drugs, (poly)peptides and genetic material into polysaccharide NGs as well as to formulate NGs-based vaccines are summarized, with a focus on the microfluidics approach. Highlights: Strategies to load therapeutics into polysaccharide nanogels have been highlighted. The formulation of polysaccharide-based vaccines has been described. Microfluidics for facilitating the scalability of nanogel formulations has been discussed.