Chemical constituents from Artemisia rupestris and their neuraminidase inhibitory activity. Issue 11 (3rd June 2021)

• Record Type: Journal Article
• Authors: Cao, Yue; Zang, Yichao; Huang, Xinyue; Cheng, Zhihong
• Is Part Of: Natural product research. Volume 35:Issue 11(2021)
• Page Start: 1775
• Page End: 1782
• Publication Date: 2021-06-03
• Subjects: Artemisia rupestris -- thiophene derivative -- sesquiterpene -- neuraminidase inhibition; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1639178
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new thiophene derivatives (1 and 2 ), a new sesquiterpene (3 ), and 15 known compounds (4 –18 ) were isolated from the whole plants of Artemisia rupestris . The new compounds (1 –3 ) were elucidated by extensive spectroscopic techniques including 1 D ( 1 H and 13 C) and 2 D NMR experiments (COSY, HSQC, HMBC and NOESY), and HR-ESI-MS. Most of the isolates (1 –6, 8, 10 –18 ) exhibited the neuraminidase inhibitory activity with IC50 values ranging from 74.07–986.54 μM by a fluorescence-based assay. Two known flavonoids (chrysosplenetin B and luteolin) showed a comparable activity to oseltamivir acid on neuraminidase inhibition. Abstract : UF0001