Insulin protects against type 1 diabetes mellitus-induced aortopathy associated with the inhibition of biomarkers of vascular injury in rats. (4th May 2021)

• Record Type: Journal Article
• Authors: Bin-Jaliah, Ismaeel; Hewett, Peter W.; Al-Hashem, Fahaid; Haidara, Mohamed A.; Abdel Kader, Dina H.; Morsy, M. D.; Al-Ani, Bahjat
• Is Part Of: Archives of physiology and biochemistry. Volume 127:Number 3(2021)
• Page Start: 266
• Page End: 272
• Publication Date: 2021-05-04
• Subjects: Aortopathy -- type 1 diabetes mellitus -- insulin -- vascular activation -- rat model; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2019.1632900
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Background: We sought to investigate the protective effect of insulin against type 1 diabetes mellitus (T1DM)-induced aortic injury (aortopathy) associated with the inhibition of biomarkers of vascular injury. Material and methods: T1DM was induced in rats by streptozotocin (STZ) (65 mg/kg), and the protection group started insulin treatment 2 days post diabetic induction and continued until being sacrificed at week 8. Results: Aortopathy was developed in the diabetic rats as demonstrated by profound alterations to the aorta ultrastructure, which was substantially protected by insulin. In addition, insulin significantly inhibited diabetes-induced dyslipidaemia, soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1), oxidative stress, and inflammation. However, blood levels of these biomarkers in the insulin-treated group were still significant ( p < .05) compared with the control group, whereas insulin treatment returned blood glucose and triglyceride to control levels. Conclusions: We demonstrate effective protection by insulin against T1DM-induced aortopathy in rats, which is associated with the inhibition of vascular injury biomarkers.