Biologic therapies for foot and ankle injuries. (3rd June 2021)

• Record Type: Journal Article
• Authors: Hogan, MaCalus V.; Scott, Devon M.; Canton, Stephen P.; LaBaze, Dukens; Yan, Alan Y.; Wang, James H-C.
• Is Part Of: Expert opinion on biological therapy. Volume 21:Number 6(2021)
• Page Start: 717
• Page End: 730
• Publication Date: 2021-06-03
• Subjects: Foot and ankle -- BMAC -- stem cells -- PRP -- tendons -- cartilage; Gene therapy -- Periodicals; Protein drugs -- Periodicals; Peptide drugs -- Periodicals; Immunotherapy -- Periodicals; Drug delivery systems -- Periodicals; 615.5
• DOI: 10.1080/14712598.2021.1866534
• Languages: English
• ISSNs: 1471-2598

Abstract

ABSTRACT: Introduction : The use of orthobiologics as supplemental treatment for foot and ankle pathologies have increased in the past decades. They have been used to improve the healing of bone and soft tissue injuries. There have been several studies that examined the use of biologics for knee and hip pathologies but the foot and ankle construct has unique features that must be considered. Areas covered : The biologics for foot and ankle injuries that are covered in this review are platelet-rich plasma (PRP), stem cells, growth factors, hyaluronic acid, bone grafts, bone substitutes, and scaffolds. These modalities are used in the treatment of pathologies related to tendon and soft tissue as well as cartilage. Expert opinion : The utilization of biological adjuncts for improved repair and regeneration of ankle injuries represents a promising future in our efforts to address difficult clinical problems. The application of concentrated bone marrow and PRP each represents the most widely studied and commonly used injection therapies with early clinical studies demonstrating promising results, research is also being done using other potential therapies such as stem cells and growth factors; further investigation and outcome data are still needed.